Validation

To measure is to know

A simple and reliable solution for home monitors is what we are continuously working on together with our users, clinics and academic partners.

In several studies we have demonstrated the reliability of digital medical tests. This has included looking at the difference with "normal" clinical tests, but we have also looked at the relationship with disease activity as measured by MRI.

Meanwhile, we have been recognized as a reliable medical device and continue to research the application of digital measurements in clinical practice.

All of our results have been published in scientific articles. Below is an overview.

Early detection of radiological disease activity
Predicitve role of biomarkers in clinical practise

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2022 Ectrims, Publication in review

Personalized monitoring of ambulatory function with a smartphone 2-minute walk test in multiple sclerosis
Individual-level curve fitting enabling the detection of statistically reliable change in ambulatory function

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2023 MS Journal, Ka-Hoo Lam , Ioan Gabriel Bucur, Pim van Oirschot, Frank de Graaf, Eva Strijbis, Bernard Uitdehaag, Tom Heskes, Joep Killestein and Vincent de Groot

Towards individualized monitoring of cognition in multiple sclerosis in the digital era

A one year cohort study

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2022 MSARD vol 60, Ka-Hoo Lam , Ioan Gabriel Bucur, Pim van Oirschot, Frank de Graaf, Hans Weda, Bernard Uitdehaag, Tom Heskes, Joep Killestein and Vincent de Groot

A Two-Minute Walking Test With a Smartphone App for Persons With Multiple Sclerosis

Validation study

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2021 JMIR Formative Research, Vol 5, No 11, Pim van Oirschot, Marco Heerings, Karine Wendrich, Bram den Teuling, Frank Dorssers, René van Ee, Marijn Bart Martens, Peter Joseph Jongen

The Potential Impact of Digital Biomarkers in MS.

Early HTA assessment of the eHealth intervention "MS sherpa"

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2021 Brain Sciences, Vol 11, Issue 10, Sonja Cloosterman, Inez Wijnands, Simone Huygens, Valérie Wester, Ka-Hoo Lam, Eva Strijbis, Bram den Teuling, Mathijs Versteegh

Full list of published articles:

- Journal of Neurology (2024) Digital outcome measures are associated with brain atrophy in patients with MS

- Lam et al (2023) Personalized monitoring of ambulatory function 2WMT

- Lam et al (2022) Towards individualized monitoring of cognition

- Lam et al (2021) Reliability, construct and concurrent validity sSDMT

- Van Oirschot et al (2021) A Two-Minute Walking Test With a Smartphone App.

- Cloosterman et al (2021) The Potential Impact of Digital Biomarkers in Multiple Sclerosis

- Wester et al (2021) IMTA Report Early HTA on the value of an AI-based decision support system in MS

- Van Oirschot et al (2020) Symbol Digit modalities Test variant in a smartphone app

- Wendrich etal. (2019) Toward Digital Self-monitoring of Multiple Sclerosis.